Fierce 850 grams

S.A.N. Fierce was specifically formulated to increase endurance and pre-workout strength levels in order to help the user to lift more weight and exercise for prolonged periods without feeling fatigued. Let's run through the list of ingredients in S.A.N. Fierce and see how each and every one contributes to an overall ergogenic and endurance-enhancing effect. The proprietary formula consists of 5 individual categories each of them designed to work in tandem with one anther.

Cell Hydration Matrix

Of all the ingredients seen in S.A.N. Fierce, creatine in its various forms is perhaps the most familiar to supplement users. Numerous studies have shown that creatine consumption leads to increased strength and athletic performance. There are several theories about how creatine works. The original theory, and perhaps still the most widely accepted, is that oral creatine supplementation increases total creatine and the creatine phosphate (CrP) in human skeletal muscle. An increased muscle CrP concentration increases its availability for ATP synthesis. This additional ATP can be used by the muscle to perform work.

Studies have also shown that creatine supplementation increases the glycogen content of skeletal muscle along with an increase in myosin heavy chain synthesis (Nelson et al. 2001). The increases in lean body mass associated with creatine use may be a result of creatine's ability to elevate insulin like growth factor 1 (IGF-1) in muscle tissue (Deldicque et al 2005).

Why do we see the Malic Acid combined with creatine in the formulation? the Malic Acid is an intermediate in the so-called Tricarboxylic Acid Cycle (TCA). While being processed in the TCA, each kind of major fuel is converted to acetyl groups, which are handled by attachment to a particular coenzyme known as coenzyme A. Ultimately ATP is produced from another compound, NADH, generated by the TCA. The malate is dehydrogenated in the TCA cycle to oxaloacetate, the concentration of which is one of the most critical controls of the rate of aerobic ATP production. During prolonged aerobic activity, and in patients suffering from malate deficiency, the malic acid is depleted and the TCA is unable to produce ATP quickly enough to meet the demands of working muscle.

Creatine-Ethyl-Ester is a synthetic analog of the popular creatine powder. The main difference between the two compounds is that the carboxylic acid group of creatine is molecularly modified through the attachment of an ester linkage. In doing this, we are able to create an organic compound that possesses both increased water solubility and enhanced muscle partioning effects over ordinary creatine monohydrate. Once in the body, regular creatine monohydrate rapidly loses its water molecule yielding the byproduct ‘creatinine.’ Even though a natural by-product of creatine metabolism,the creatinine possesses numerous undesirable side effects to the athlete. It was therefore significant to discover that treating the creatine with Ethyl alcohol and hydrogen chloride not only removed the undesirable water molecule from creatine, but also yielded a pure creatine- Ethyl-ester compound that is completely devoid of both water and creatinine.

Once in the gastrointestinal tract the Creatine-Ethyl-ester is rapidly hydrolyzed to pure creatine by the esterase enzyme yielding an immediate ATP substrate without any stomach discomfort or stomach bloating. ATP (adenosine triphosphate/ or three phosphates attached to adenosine, which is a nucleoside) is the necessary energy molecule that fuels muscular contractions by donating one phosphate group as cellular energy.

NITRO NO

What is even more exciting is that Taurine works extremely well with glucuronolactone (see above) in aiding mental performance, clarity and reaction time.

N-Acetyl-L-Glutamine (NAG) is known to form a protective layer over the lining of the stomach. It accomplishes this by activating a chemical action that serves as an anti-acid buffer while suppressing the secretion of pepsin, a protein-digesting enzyme produced in the stomach.

More recent clinical research indicates that NAG has psycho-stimulant properties while improving memory. Chemically speaking, N-Acetyl-L-Glutamine is the acetylated version of the most abundant amino acid found in skeletal muscle tissue, which is glutamine. NAG is more stable in water and metabolically efficient at delivering glutamine’s biological effects over conventional Glutamine or Glutamine Peptides. As a glutamine donor it supports the immune system. (Haussinger et al 2001).

Tyrosine is a nonessential amino acid synthesized in the body from phenylalanine. It is an important nutritional ingredient and chief factor in the biosynthesis of the brain neurotransmitters epinephrine, norepinephrine, and dopamine. As such, Tyrosine is a precursor for the neurotransmitters that are responsible for transmitting nerve impulses. Tyrosine is also considered an antioxidant, reacting with free radicals that can cause damage to cells.

Caffeine is our last and final ingredient which is known as a competitive inhibitor of the enzyme cAMP-PDE, thus converting cyclic AMP in cells to its noncyclic form, allowing cAMP to build up. Cyclic AMP participates in the messaging cascade produced by cells in response to stimulation by epinephrine, so by blocking its removal caffeine intensifies and prolongs the effects of the neurotransmitters epinephrine and norepinephrine.

The metabolites of caffeine contribute to caffeine's overall powerful effects. Theobromine which is considered a vasodilator increases the amount of oxygen and nutrient flow to the brain and muscles. Theophylline, the second of the three main metabolites, acts as a smooth muscle relaxant that chiefly affects the bronchioles and acts as a chronotrope and inotrope thus increasing heart rate and efficiency. The third metabolic derivative, paraxanthine, is responsible for an increase in the fat burning process, which releases glycerol and fatty acids into the blood to be used as a source of fuel by the muscles (Dews et al. 1984).

850 Grams   
Supplement Facts
Serving Size17Gram
Servings Per Container50
Amount Per Serving    % Daily Value
Calories    0   
Cell Hydration Matrix    4g    †
Di-Creatine Malate       
Creatine Malate       
Creatine Ethyl Ester HCL       
Neuro Substrates    3.8g    †
Taurine       
N-Acetyl L-Glutamine       
Tyrosine       
Caffeine Anhydrous       
Creatine Assimilator™    2.5g    †
Betaine Anhydrous       
Glycocyamine       
Guanidinopropionic Acid(3-GPA™)       
Duralast™ Matrix    2.4g    †
Glucuronolactone       
L-Aspartic Acid       
B-Alanine       
Nitro NO    2.3g    †
L-Arginine Alpha-Ketoglutarate        †
Ornithine Alpha-Ketoglutarate        †
† Daily Value not established
Other Ingredients
Citric Acid, Calcium Silicate, Natural And Artificial Flavors(Spray Dried Orange OilSpray Dried Orange Juice), Aspartame, Acesulfame-K, FD&C Colors (Red #40, Yellow #6)

Directions For S.A.N. Fierce: Take 1 scoop and mix into 12oz of cold water 30 minutes before your workout and/or immediately upon awakening.

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.